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Oncogenic PIK3CA increases the dependency of cancer cells on glutamine by upregulating the expression of mitochondrial GPT2, which catalyzes the transamination reaction that converts glutamate and pyruvate into -KG and alanine 175

Self-treating a chronic condition and avoiding it is not advisable as it may have serious consequences

Supported by the Intramural Research Program of the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892

Statistical analyses (GraphPad Prism v.9 software) were performed using unpaired two-tailed Students t -tests or two-way or three-way ANOVAs followed by a TukeyKramer multiple comparison test, as specified in the figure legends