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At least 70 enzymes have been identified as requiring CoA or ACP derivatives for their function including the same critical thiamine-dependent enzymes described above, the pyruvate dehydrogenase complex (PDHc), 2-oxoglutarate (-ketoglutarate) dehydrogenase complex (OGDH), and branched-chain -ketoacid dehydrogenase complex (BCKD)

Research published in the Journal of Biological Chemistry has confirmed that the copper-peptide complex maintains stability across physiological pH ranges (6.5-7.5), resisting dissociation under normal tissue conditions

R.GoldringM

When shopping for Japanese supplements, there are, however, two important differences to note compared to North American products: 1

Saima et al