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CYP2D6*1 (wild type), which is more prevalent in Caucasians, showed that the ratios of intrinsic clearance (Vmax/Km) of *1 to *10 for MDMA O-demethylenation was 123, and for methamphetamine 67, for the p-hydroxylation 157 of the N-demethylation (Ramamoorthy et al., CYP2D6 polymorphism on drug effects are not always reproduced in Asian ones

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