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That said, this guide isn't intended to be taken as definitive

In trials to assess semaglutides effectiveness for reducing the risk of major cardiovascular events in adults, increases in total bilirubin greater than or equal to 3 times the upper limit of normal were seen in .3% of people taking Wegovy versus .2% of people taking the placebo

However, an important limitation is the omission of real-world data, which are often different from clinical trial results, partly because of varying patient populations

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