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The association of FH with histone H2A.Z is dependent on FH being phosphorylated on a threonine residue (T236) by the DNA-dependent protein kinase, DNA-PK
Tiered Evidence: Tier 1 - what the trials actually show ObesityThe strongest evidence is in obesity
However, given their newly emerging and unprecedented efficacy profile in the treatment of common obesity, they may represent an important addition to the pharmacological toolbox to help manage PWS symptomatology
since each molecule of DMSA is usually excreted in the urine bound to 2 molecules of cysteine, it is possible that DMSA therapy may decrease cysteine levels
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