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10.1016/j.freeradbiomed.2015.04.036 Free Radic

Another meta-analysis reported that smoking alone nearly doubled the risk of HCC [102]

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There were no significant difference of gender, treatment time of PEG-IFN to attain HBsAg loss ( p =0.744), consolidation treatment time of PEG-IFN ( p =0.658), serum ALT ( p =0.681), serum HBsAb( p =0.052), compensated cirrhosis ( p =0.064) at the baseline of follow-up and also the HBsAg level before PEG-IFN treatment ( p =0.979)

Active targeting systems still require further optimization in terms of reproducibility, characterization and large-scale production to approach clinical translation, and alternative strategies such as endogenous targeting by modifying lipid composition to modulate protein corona may be more reliable in a near future