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They are highly toxic to the liver and are amongst the major identified risk factors for hepatocellular carcinoma 10,11,12
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For example, p16 ink4a knockout mice exhibited heightened levels of cellular senescence, accompanied by subsequent fibrosis observed in both tubular and interstitial cells, especially within the collecting ducts, after undergoing unilateral ureteral obstruction (Wolstein et al., 2010)
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