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Brain AT 1 -R has been reported to play a role in blood pressure and fluid homeostasis regulation, stress responses, depression and cognition, among others ( 1 -R density, where they positively modulate dopamine synthesis, tonic, and evoked release ( 1 -R modulate DA hyperreactivity induced by a single exposure of AMPH in caudate-putamen and nucleus accumbens ( 1 -R blockade prevented the AMPH-induced locomotor sensitization and reversed the psychostimulant-induced locomotor sensitization when these receptors where locally antagonized in the caudate-putamen ( Moreover, the presence of AT 1 -R has been described in all the components of the neurovascular unit ( 1 -R are constitutively expressed in astrocytes and their activation induces increased intracellular Ca 2+ with the subsequent induction of early gene transcription ( 1 -R is associated with imbalance in vascular tone regulators together with vascular leakage and inflammatory cell recruitment ( AT 1 -R blockers are currently used in the antihypertensive treatment and have a low incidence of adverse effects, even in elderly patients and they do not alter blood pressure in normotensive patients ( 1 -R blockers available, candesartan (CAND) shows the tightest and longest-lasting binding to AT 1 -R ( 1 -R activation/stimulation has overlapping effects with AMPH in the neurovascular unit components, make AT 1 -R blockers a potential pharmacological tool to modulate some deleterious effects induced by AMPH

Tirzepatide acts on GIP and GLP-1 receptors and can substantially lower glucose and body weight

GHD should be confirmed by an appropriate growth hormone stimulation test

Diaz, 2009]

Meanwhile, A combination could theoretically produce greater appetite suppression or allow different dose balances, but it may also intensify gastrointestinal effects or excessive energy restriction