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Recent advances in peptide chemistry, formulation science, and fragment-based optimization have begun to redefine these limitations

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When to stop or modify protocols Discontinue or modify protocols if symptoms worsen progressively, if new neurological symptoms develop, if allergic reactions occur, or if significant side effects emerge

The focus should remain on overall dietary quality, appropriate macronutrient balance, and adherence to established nutritional guidelines

The clinical evidence for some of these agents (like SGLT2 inhibitors and statins) in improving cardiovascular outcomes is strong, supporting the concept that modulating pathways intertwined with oxidative stress is a viable therapeutic approach