It is possible to increase glutathione levels through oral or intravenous (IV) supplementation
The Redox Balance: In this process, two GSH molecules join to form Oxidized Glutathione (GSSG)
One hypothesis is that we observed a greater induction of NRF2 through liver-specific Gclc deletion as compared to KEAP1 inhibition with CDDO-me because CDDO-me is a weaker inhibitor of NRF2-KEAP1 interaction compared to the ROS generated following GSH depletion
IGF-1 Upregulation Downstream Anabolic Signaling Both peptides indirectly stimulate insulin-like growth factor-1 (IGF-1) production through sustained growth hormone elevation: Growth hormone binds to hepatic GH receptors activating JAK-STAT signaling pathways Increased transcription of IGF-1 gene in liver tissue Elevated plasma IGF-1 levels mediate anabolic effects in muscle, bone, and adipose tissue IGF-1 provides negative feedback regulation preventing excessive growth hormone secretion Studies report IGF-1 increases of 1.5- to 3-fold for 9-11 days following CJC-1295 administration, with the ipamorelin combination providing more sustained elevation
[3] Alba M, Fintini D, Sagazio A, Lawrence B, Castaigne JP, Frohman LA, Salvatori R
