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Nat Rev Endocrinol

Several studies have relatively short follow-up periods and limited sample sizes, which may constrain the evaluation of long-term efficacy and durability

It was found that more patients in the LIR group than the placebo group maintained their weight loss by 5%, which indicated that LIR 3.0 mg/d is expected to improve the maintenance of weight loss ( GLP-1 analog has 97% homology with human GLP-1 and has been approved for the clinical treatment of diabetes and obesity

doi: 10.2337/DIABETES.51.2007.S434 61 DahlKBrooksAAlmazediFHoffSTBoschiniCBkdalTA

In a clinical trial of 30 patients, 21 were insulin-free for at least a year