Circulation 2016;134:752-72.ArticlePubMed 29
had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript Disclosure statement The authors have no relevant affiliations or financial involvement with any organisation or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript
The medications also influence reward pathways in your brain, making high-calorie foods less appealing
Given the results from recent studies, the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) recommend that patients with T2D and clinical cardiovascular disease (CVD) with inadequate glucose control despite treatment with metformin should receive an SGLT2 inhibitor or GLP-1 receptor agonist

Medications such as Contrave and Qsymia can be effective for treatment. If you cant afford your GLP-1 medication without insurance, talk to your healthcare provider about some alternatives: Qsymia (phentermine-topiramate), an appetite suppressant available as a once-daily oral capsule Contrave (naltrexone-bupropion), an oral tablet typically taken twice per day to manage cravings and reduce appetite Adipex-P (phentermine), an appetite-suppressing tablet typically taken once per day Diethylpropion extended-release, a long-lasting appetite-suppressing tablet typically taken once per day Phendimetrazine tartrate, available as a tablet thats taken before meals (up to three times per day) to increase the bodys metabolism and reduce appetite Alli (orlistat), an oral capsule that limits how much fat the body absorbs and can be taken up to three times per day, about an hour before eating Xenical (orlistat), a capsule that contains the same active ingredient as Alli but in a higher dose Your healthcare provider may also prescribe a generic GLP-1 agonist: liraglutide or exenatide
