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Combining with DPP-4 inhibitors is generally not recommended, as both drug classes work on the incretin system Adding basal insulin for those with more significant hyperglycaemia, which can be used alongside GLP-1 medications (with careful monitoring for hypoglycaemia) Switching to insulin therapy entirely may be necessary for those with advanced beta cell failure For weight management , when GLP-1 medications don't produce adequate weight loss, alternatives include: Orlistat , a lipase inhibitor that reduces fat absorption, though weight loss is typically modest (2-3 kg on average) Naltrexone-bupropion (Mysimba), which works on appetite centres through different pathways
The FDA has approved Semaglutide GLP-1 injections for long-term use for weight loss
A randomized clinical trial published in JAMA Psychiatry offers preliminary evidence: | JAMA Psychiatry
By targeting the specific reasons patients stop treatment, the program ensures they receive the support they need to stay on track
Yet, GLP-1 drugs arent a cure-all to begin with, and even clinical trials found that patients lost weight while taking these medications in conjunction with making lifestyle habit changes
