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Nevertheless, This study provides the first evidence of a formulation-and dose-dependent ION risk, with the strongest association observed for Wegovy, write the researchers, concluding: These findings highlight a potential dose-dependent safety concern that warrants urgent prospective evaluation to guide prescribing and regulatory policy. The authors of a linked commentary agree

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Patients should follow provider instructions carefully and understand that compounded products are not FDA-approved drug products

More than a third of participants lost 25% or more of their starting weight - results that approach what we see with some surgical procedures

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