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Proctor EA, et al

Due to their general nature, it could be that the labels themselves are often of lesser (or no) importance in a therapeutic sense, to the degree that they may overlook or even obscure important details of an individuals history

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According to the AIE mechanism, the fluorescence of these dyes can be turned on/off if the analyte can alter the aggregation behavior (solubility) or the intramolecular motions of the fluorescent species 55,56