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The uracil ring of the xanthine scaffold has -stacking interactions with Tyr547 (Figure 4), while the quinazoline ring has -stacking interactions with Trp629 (Figure 4)

13 Under fluoroscopic guidance, a microcatheter is navigated over a microwire and positioned superselectively within the proximal main trunk of the MMA, distal to the entry into the foramen spinosum

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In the human component, 14 adults participated in a six-week trial where they experienced both adequate sleep (approximately 7.5 hours per night) and restricted sleep (about 6 hours per night), separated by a six-week washout period

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