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This evidence supports the roles of ghrelin mimetics in boosting hunger (helpful in calorie-surplus phases), activating the GH/IGF-1 axis, and potentially helping maintain or increase lean mass through anabolic signaling

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3h,i and Extended Data Fig

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Sin embargo, la prdida de peso significativa tpicamente ocurre durante un perodo ms prolongado: Primeras 4-8 semanas : Prdida de peso inicial modesta (1-3% del peso corporal) 3-6 meses : Prdida de peso ms notable (generalmente 5-10% del peso corporal) 6-12 meses o ms : Prdida de peso mxima, que vara significativamente segn el medicamento y la dosis La magnitud de la prdida de peso depende del frmaco especfico y su dosis