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Future research should prioritise long-term outcomes in high-risk groups, comparisons of physiological versus pharmacological dosages in healthy subjects, cost-effectiveness analyses, and adherence monitoring to inform clinical guidelines for the management and prevention of B12 deficiency

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Tirzepatide, like all proteins, can denature when subjected to aggressive agitation

This leaves practitioners in a difficult position: acknowledging a promising safety signal while recognizing the profound limitations of unpublished data

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