Systematic review registration: identifier PROSPERO (CRD42022337099)
Medications such as semaglutide and tirzepatide, also known as GLP-1 receptor agonists, work by mimicking the action of the hormone GLP-1 (glucagon-like peptide-1), which helps regulate appetite and blood sugar levels
While individual antioxidants show partial efficacy, synergistic formulations could enhance blastocyst formation rates by targeting multiple redox pathways simultaneously ( 5.2.2 Standardized dosing 5.2.2.1 Reproductive protocols Defining optimal dosages for supplements like melatonin (218 mg/day) is essential to balance efficacy and safety, especially regarding gestational and neonatal outcomes ( in vitro maturation (IVM) improve embryo quality, but standardized thresholds are needed to avoid toxicity and ensure reproducibility (Tabatabaie et al., 2022)
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