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0.8% average weight change at 1 year after GLP-1 discontinuation, compared to an estimated average of 11-12% weight gain in clinical trials

ER-alpha is encoded by the ESR1 gene on chromosome 6 and ER-beta is encoded by the ESR2 gene on chromosome 10 (Jain et al., 2022)

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Thyroid Tumors: Animal studies have shown a potential risk of thyroid cancer, although there is no definitive evidence in humans