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Stay well-hydrated, eat small frequent meals, and avoid high-fat foods during the first weeks to reduce nausea

Your provider may also order A1C tests every 3 months during the initial combination phase to ensure the regimen is working without excess hypoglycemia risk

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Tirzepatide (Mounjaro/Zepbound) Timeline Phase 3 trials began: 2019 (SURPASS program for diabetes) FDA approval (Mounjaro for diabetes): May 2022 Commercial availability: June 2022, initial supply constraints Zepbound (obesity indication) Phase 3: 2020-2022 (SURMOUNT program) Zepbound FDA approval: November 2023 Zepbound commercial launch: December 2023, immediate shortages Stable widespread availability: Still not fully stable as of early 2026

Like Semaglutide, Tirzepatide is now available through compounding pharmacies in more affordable formulations