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Without randomized, long-term studies on the use of GLP-1 RAs in a large sample size of HS patients with a wide range of ages, comorbidities, risk factors, and sexes and without any confounding factors, it is difficult to conclusively determine whether GLP-1 RAs are a definitive treatment for HS

GLP-1, or glucagon-like peptide-1, is a natural hormone that affects appetite and digestion

Neutrophils activate the IFN antiviral signaling pathway through the endogenous retrovirus HERV-K envelope protein, enhancing the release of neutrophil extracellular traps (NETs) and the process of NETosis

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Although both semaglutide and lanifibranor significantly lowered -SMA levels, semaglutide had no effect on fibrosis histology in GAN DIO-NASH-HCC mice