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While patients with large and giant CMN have the greatest overall lifetime risk of melanoma, estimated between 4.5 % and 10 % [5], all congenital nevi should be considered as potential precursor lesions and patients and parents should be educated to monitor for changes in appearance

Neumann, B., Segel, M., Chalut, K

Complication rates align with published MSV series, supporting procedural safety

PMID: 139 ForoughiMTorabinejadMAngelovNOjciusDMParangKRavnanMet al

Summary Thus final summarization of these studies indicates that high dose thiamine repletion may decrease the risk of micro and macrovascular disease and counter incipient nephropathy in diabetes