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Therefore, a homeostatic breakdown of LECs may play a role in the development of diabetic cataracts
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A small quantity of GSH is oxidized, reacting with cellular reactive oxygen species (ROS), yielding GSSG (disulfide GSH) (normal ratio of GSH/GSSG around 100:1)
The KD is a typical tyrosine KD and is catalytically active, whereas the adjacent PKD is catalytically inactive and lacks critical residues despite containing a canonical kinase fold (78)