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Goal: Support metabolic efficiency through NNMT inhibition, potentially enhancing fat oxidation and NAD+ levels
What dose was used in trials
Reported benefits (per available research): FDA-approved, clinical-trial-supported reduction of excess visceral abdominal fat in HIV-associated lipodystrophy, the only indication with robust human RCT evidence behind it Studied in a randomized, placebo-controlled trial for possible support of executive function and cognitive performance in healthy older adults and adults with mild cognitive impairment (Baker et al., 2012) Proposed, but far less rigorously studied in healthy or bodybuilding populations, to support lean body mass and body composition changes through GH/IGF-1 axis stimulation
Why the absence of evidence matters The phrase "absence of evidence is not evidence of absence" gets invoked frequently in oral tirzepatide discussions
BPC-157 (body protection compound), is an endogenous, stable pentadecapeptide 15 amino acids first derived from gastric juices
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