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doi: 10.1073/pnas.2216722120

Characterization of two ferroptosis subtypes with distinct immune infiltration and gender difference in gastric cancer

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Crucially, ApoER2 signaling in the brain is responsible for both early stage neuronal development and also adult synaptogenesis and learning in the Reelin pathway that is primarily activated through ApoE binding to ApoER2, for which ApoER2 is heavily expressed in the hippocampus and neocortex, in particular in granule cells and pyramidal cells (Fernndez-Calle et al., 2022)