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Gene Expression Regulation: Research using gene array analysis has reported that GHK-Cu influences the expression of over 4,000 human genes in cellular models including broad upregulation of tissue repair, antioxidant defence, and anti-inflammatory genes, and downregulation of genes associated with inflammation and oxidative stress making it one of the most extensively gene-profiled small peptides in biomedical research

However, retatrutide is most effective at reducing fat mass

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In rats, the oral dose found to be effective was 10g/kg, or 1.6g/kg

Short term effects include dehydration and intoxication, while more long-term effects can include changes in the metabolism of the liver and brain