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Restoring ferroptotic sensitivityby targeting DPP9, AIM2, or their downstream effectorsoffers a rational strategy to overcome drug resistance and improve outcomes in advanced renal cancer

J Basic Clin Physiol Pharm 2014

Carotenoids are natural tetraterpene pigments produced by bacteria, fungi, algae, some animals, and various plants

Zone 2 Training Moderate-intensity cardiovascular exercise improves mitochondrial function and supports hormone balance without overstressing the system

In the context of mucosal inflammation, the activation of NADPH oxidase (NOX) and inducible nitric oxide synthase (iNOS) by inflammatory cytokines leads to the production of superoxide and nitric oxide by intestinal epithelial cells (IECs), neutrophils, and macrophages ( Both ROS and RNS have been implicated in IBD pathogenesis, with a particular role in CD initiation and progression ( These ROS promote cell damage and harm tissue integrity by preventing the accumulation of antioxidant defenses in host cells