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Each has distinct clinical features but shares overlapping molecular mechanisms driven by chronic hyperglycemia-induced ROS overproduction

International journal of molecular sciences, 24(23), 16588

Unsaturated VPA metabolites (4-en-VPA and 2, 4-dien-VPA) are potent inducers of microvesicular steatosis in rats, whereas VPA itself failed to induce discernible liver lesions at near lethal doses [60]