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The hypervascularization is driven by the release of vascular endothelial growth factor (VEGF) and other angiogenic factors (Luengas-Martinez et al

It appears to stimulate the formation of granulation tissue, reepithelialization, and collagen depositionkey phases in the healing process

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Previously published case reports of intentional and unintentional supratherapeutic exposures have mostly described gastrointestinal symptoms requiring hospital admission for supportive therapies, such as intravenous fluids and antiemetic medications [14,15,16,17,18,19,20,21]

Most patients report only feeling a small pinch, describing a flu shot to be more painful