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More recently, studies have used optimized AAV vectors, obtaining higher tissue and plasma transgene expression, complemented by normalization of Gb3 storage in plasma, kidney and heart [100,101,102], which provides the basis for advancing the research towards trials with patients, in particular patients with nonsense or missense mutations

Harnessing endogenous stem/progenitor cells for tendon regeneration

Front Immunol 2018;9:2282.ArticlePubMedPMC 41

Low testosterone affects an estimated 4 to 5 million American men, though many cases go undiagnosed (Mulligan et al., 2006)

Notably, the gut serves as the main human reservoir for orally ingested metformin with 100300 times higher than in serum (Wilcock and Bailey, 1994