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Dox was administered intraperitoneally at a dose of 12 mg/kg weekly as previously described 28 , EMPA was given orally at 10 mg/kg daily, and TRF followed a 16 h/8 h protocol, with food provided at 8 PM to align with the nocturnal feeding patterns of the rats

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Exposure to certain neurotoxins has been suggested to be a risk factor for PD [103,104]