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Conversely, individuals already achieving good glycemic control on tirzepatide monotherapy, those with recurrent hypoglycemic episodes, or those taking multiple insulin-sensitizing agents (e.g., pioglitazone + metformin + tirzepatide) should consult their provider before adding inositol

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Additionally, only for initial analysis (Venn diagrams), we included SGLT2i (empagliflozin, dapagliflozin) and metformin

A value of 100% indicates no drug transport into the brain across the BBB (AUC(brain, IV) = 0) or no drug absorption into the systemic circulation after intranasal administration (AUC(blood, IN) = 0)

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