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PA treatment elevated the expression of genes associated with cholesterol synthesis, such as acyl-CoA C-acyltransferase 1 gene ( ACAT1 ), SREBP-2 , HMGCR , and squalene monooxygenase gene ( SQLE ), as well as genes related to bile acid synthesis, including liver X receptor gene ( LXR ) and cholesterol 7-alpha-hydroxylase gene ( CYP7A1 )
Remember, the fact that coronavirus infection rates were not affected by semaglutide indicates that the same findings from this study could also apply to the mortality of other dangerous viruses, like influenza or RSV
Therapeutic utility and medicinal chemistry of cathepsin C inhibitors
