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Initially, it was hoped that the combination would protect both drugs against the development of resistance, but unfortunately, that has not been the case [81, 82], so novel approaches are needed

Specifically, the ROS scavenger butylated hydroxyanisole delayed TNF-induced necroptosis but had no effect on necroptosis induced by direct RIPK3 oligomerization, suggesting that ROS may facilitate upstream signaling events rather than serve as an obligate execution mechanism 80

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Effect of alpha-lipoic acid on asymmetric dimethylarginine and disability in multiple sclerosis patients: A randomized clinical trial