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This led to the demonstration that DPP-4 inhibitors may protect the endogenous molecule [14] and to the development of clinically useful DPP-4 inhibitors, which have found clinical use worldwide

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In this relation, a BMI of 30 kg/m 2 or higher is classified as obese [4], whose causes lie in excessive calorie intake or reduced energy expenditure, and modern lifestyles promote both a lack of exercise and an unhealthy diet

It might be because of fewer platelets made in the bone marrow, more platelets being removed, or because of spleen or liver issues