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Data Availability All data supporting the findings of this study are available within the article and its Supplementary Information file, or are available from the authors upon reasonable request

Multiple tumors are frequently discovered in SOTRs, and these tumors typically exhibit greater aggressiveness than those found in the entire population [86]

This is a conceptual argument rather than a measured one again, the human PK data do not exist but it illustrates why systemic delivery is not self-evidently advantageous for a cosmetic goal, and why the burden of proof sits squarely on anyone claiming injection is the better skin route

Although the suggested mechanisms are multiple and disparate, the general idea is that they may converge on a common pathway [7]

Glutathione aids in this process by binding to these toxins and facilitating their removal from the body