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While these results are a start, its important to note that: The study was conducted on only 48 participants

These data support the switch from weekly to monthly dosing and titration to the highest weekly dose of 2.4 mg, Buse said

Because it interacts with pathways in the brain related to reward and motivation, it may also affect how individuals experience food, cravings, and even alcohol consumption

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AGT is present in the proximal tubule and concurrent increases in AGT-mRNA/protein in renal tissue homogenates has been explained as indicating that transcriptional activation of the AGT gene would be responsible for renal ANG II increase