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Inorganic sulfate (SO 4 2 ) & 3-phosphoadenosine-5-phosphosulfate (PAPS) In humans, inorganic sulfate is a vital ISS that is produced through sulfite oxidation by either molybdenum-dependent sulfite oxidase (SOUX) residing in the intermembrane space of the mitochondria or by the moonlighting functions of endothelial nitric oxide synthase (eNOS) [15,54,55]