The medication is initiated at a low dose (0.25 mg) and gradually increased over 16 weeks to the maintenance dose of 2.4 mg to minimise gastrointestinal side effects, which are common during the early stages of treatment
Gene expression studies revealed that GHK-Cu modulates over 4,000 human genes, with 50% moving toward patterns seen in younger, healthier individuals
There is evidence that VGEF can be particularly involved in schizophrenia [291,292,293,294], given abnormal vascularization and VEGF acting as an angiogenic and neurotrophic factor involved in the regulation of cerebral blood volume and flow in schizophrenia [294]
Clear, large-scale human data is still missing
It appears on WADA's Prohibited List under "Hormone and Metabolic Modulators." International regulatory status varies: the European Medicines Agency (EMA) has not approved AOD-9604, and it is banned or restricted in many countries as an unapproved drug product