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Grashoff, C

139,140 It is hypothesized that DPP4 inhibitors may modulate the endocytic cascade of SARS-CoV-2 by interacting with caveolin-1, a scaffold protein required for endosome formation

Its surface appearance depends on two structural layers beneath it: the dermal matrix of collagen and elastin produced by fibroblasts, and the subcutaneous fat layer that acts as a volumizing scaffold pressing outward against it

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Its presence on gene regulatory sequences (promoters or enhancers) usually causes transcriptional silence and may promote transcription when present on gene bodies (Liu et al., 2023) (Figure 3)