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Diagnostic pathology, 8(1), 1

Statements Author contributions YW: Conceptualization, Methodology, Writing original draft

Data availability The Raw shotgun sequencing data that support the findings of this study have been deposited in the European Nucleotide Archive under accession codes PRJEB37249, PRJEB38742, PRJEB41311, and PRJEB46098

Gallbladder issues relate more to weight loss speed than the drug itself

Key effects include: Stimulation of collagen I, III, and V synthesis Increased elastin production Enhanced glycosaminoglycan (GAG) synthesis Promotion of blood vessel growth (angiogenesis) Anti-inflammatory gene modulation Superoxide dismutase upregulation (antioxidant protection) Hair follicle enlargement and growth stimulation How Semaglutide in This Context Semaglutide is a GLP-1 receptor agonist that produces weight loss primarily through appetite suppression and improved metabolic function