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DDP-4: dipeptidyl peptidase 4

Use appropriate laboratory safety procedures when handling

In addition to reducing pill burden and improving compliance, given combination therapy with two drugs may help patients achieve their target HbA1c faster than monotherapy

The total weight of the three capsules for each group was the same

The procedure involved extracting blood samples from filter paper using methanol, followed by drying the supernatant under nitrogen at 40 C, derivatization with butanolic-HCl, and reconstitution with 200 L of acetonitrile-water (50:50 v/v) containing 0.05 % formic acid to adjust pH to 4 for LC-MS/MS analysis