nice semaglutide Guideline Update: for managing overweight and obesity ℹ️ For more information check out the official guidance put out on NICE CKS (https://www.nice.org.uk/guidance/TA875) #Medicine #doctor #medical #clinical #surgery #surgeon NICE recommends semaglutide to prevent

In contrast to GIP, a substantial number of preclinical and clinical studies link GLP-1 as a central peptide that, through hormonal and neural pathways, not only regulates pancreas function but also hunger and satiety (Fig

The GLP-1 receptor effect on gut motility GLP-1 receptor activation is the primary driver of gastrointestinal side effects in retatrutide, just as it is in pure GLP-1 agonists like semaglutide and dual agonists like tirzepatide

Stopping these drugs without a clear reason may work against those benefits

Most patients lose 2-4 pounds in the first month on semaglutide, primarily from water loss and reduced food intake

Additionally, rapid weight loss associated with GLP-1 therapy triggers ketosis in some patients, and ketones can produce a fruity or acetone-like smell on the breath