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The synthesis of orforglipron involves the assembly of three principal building blocks (the tetrahydropyran, indazole, and phenyl fragments) through sequential coupling reactions, followed by purification using standard crystallization and recrystallization techniques rather than expensive chromatographic methods

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Switching from Mounjaro to Wegovy A tolerance, side effects, or preference can make some patients change their choice from Mounjaro to Wegovy

They may suggest a different type of painkiller that is safe to take alongside an NSAID, such as paracetamol

Blood pressure monitoring is advisable