The protective nature of A is also evident in vivo as 5XFAD mice [genetic AD mouse model harboring the 5 most prominent familial AD mutations (Oblak et al., 2021)] have significantly better survival profiles than wild type mice in a model of Salmonella typhirium -induced meningitis, and as APP knockout mice fare worse than do wildtypes (Kumar et al., 2016)
Research protocols may examine whether interventions that modulate the glutathione synthesis pathway can affect neuronal survival, protein aggregation (e.g., alpha-synuclein or amyloid-beta), or mitochondrial function in these non-human systems
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Vitamin K Vitamin K is essential for bone health and also helps blood to clot