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This difference was achieved without any change in food intake, suggesting the weight loss came from metabolic changes rather than appetite suppression

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Arielle Kanters, MD, a colorectal surgeon with the Cleveland Clinic, uses conscious sedation that puts patients in a twilight state using partial anesthesia

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Given that Metformin is contraindicated in cases of acute kidney injury or severe renal impairment, dosage modifications may be required depending on kidney function