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Safety assessments were conducted from baseline through end-of-study follow-up, and pharmacokinetic and exploratory assessments were performed at prespecified time points, including serial sampling up to 672 h after the final dose

Clinical outcomes We evaluated mortality from cardiac causes and unplanned re-hospitalization for HF during the follow-up period

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Demonstrating proper use of the pre-filled pen device and having patients perform return demonstrations can identify potential technique issues before they result in dosing errors