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However, long-term surveillance data are required to consolidate its safety profile (108)

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Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats

Under normal circumstances, there is a fine balance that enables AOXs to neutralize excess ROS, and maintain a small amount of ROS necessary for normal cell functions

7.3.2 Biomarker standardization challenges The practical implementation of ferroptosis biomarkers faces difficulties in standardizing measurements of reactive lipid species like MDA and 4-HNE across clinical laboratories, defining clinically validated cut-off values for therapeutic decision-making, and the invasive nature of obtaining optimal samples like BALF for routine monitoring