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"These findings highlight the urgent need for evidence-based guidance for when GLP-1RAs should be used relative to bariatric surgery in adolescents and young adults, including whether medications are most effective before surgery, after surgery, or as part of combination therapy." The findings were reported in the paper, GLP-1 Receptor Agonist and Bariatric Surgery Utilization Among Adolescents and Young Adults, published in JAMA Pediatrics

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It was first identified in 1973 by Loren Pickart, who observed that this fragment naturally present in human plasma at roughly 200 ng/mL in young adults declined with age and appeared to influence tissue repair

Patients should avoid these in favor of physician-prescribed, FDA-approved therapies